Nature Communications - Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.pdf (783.34 kB)
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
journal contribution
posted on 2023-06-09, 06:05 authored by Russell L McLaughlin, Nigel LeighNigel Leigh, GWAS Consortium Project MinE, Genomics Consortium Schizophrenia Working Group of the PsychiatricWe have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
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- Published
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- Published version
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Nature CommunicationsISSN
2041-1723Publisher
Nature Publishing GroupExternal DOI
Volume
8Article number
a14774Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-05-03First Open Access (FOA) Date
2017-05-03First Compliant Deposit (FCD) Date
2017-05-03Usage metrics
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