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Nature Communications - Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.pdf (783.34 kB)

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

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posted on 2023-06-09, 06:05 authored by Russell L McLaughlin, Nigel LeighNigel Leigh, GWAS Consortium Project MinE, Genomics Consortium Schizophrenia Working Group of the Psychiatric
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Communications

ISSN

2041-1723

Publisher

Nature Publishing Group

Volume

8

Article number

a14774

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-05-03

First Open Access (FOA) Date

2017-05-03

First Compliant Deposit (FCD) Date

2017-05-03

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