2014 - Baden Nikolaev et al - PLoS Biol.pdf (1.55 MB)
A Synaptic Mechanism for Temporal Filtering of Visual Signals
journal contribution
posted on 2023-06-09, 06:58 authored by Thomas BadenThomas Baden, Anton Nikolaev, Federico Esposti, Elena Dreosti, Benjamin Odermatt, Leon LagnadoLeon LagnadoThe visual system transmits information about fast and slow changes in light intensity through separate neural pathways. We used in vivo imaging to investigate how bipolar cells transmit these signals to the inner retina. We found that the volume of the synaptic terminal is an intrinsic property that contributes to different temporal filters. Individual cells transmit through multiple terminals varying in size, but smaller terminals generate faster and larger calcium transients to trigger vesicle release with higher initial gain, followed by more profound adaptation. Smaller terminals transmitted higher stimulus frequencies more effectively. Modeling global calcium dynamics triggering vesicle release indicated that variations in the volume of presynaptic compartments contribute directly to all these differences in response dynamics. These results indicate how one neuron can transmit different temporal components in the visual signal through synaptic terminals of varying geometries with different adaptational properties.
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Publication status
- Published
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- Published version
Journal
PLoS BiologyISSN
1544-9173Publisher
Public Library of ScienceExternal DOI
Issue
10Volume
12Article number
e1001972Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-07-03First Open Access (FOA) Date
2017-07-03First Compliant Deposit (FCD) Date
2017-07-03Usage metrics
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