Romero, Eugénie, Minard, Corinne, Benchekroun, Mohamed, Ventre, Sandrine, Retailleau, Pascal, Dodd, Robert H and Cariou, Kevin (2017) Base-mediated generation of ketenimines from ynamides: direct access to azetidinimines by an imino staudinger synthesis. Chemistry - A European Journal, 23 (53). pp. 12991-12994. ISSN 0947-6539

PDF - Accepted Version Download (1MB)

Abstract

Ynamides were used as precursors for the in situ generation of highly reactive ketenimines which could be trapped with imines in a [2+2] cycloaddition. This imino Staudinger synthesis led to a variety of imino-analogs of β-lactams, namely azetidinimines (20 examples), that could be further functionalized through a broad range of transformations.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Research Centres and Groups:	Sussex Drug Discovery Centre
Subjects:	Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User:	Mohamed Benchekroun
Date Deposited:	28 Jul 2017 08:18
Last Modified:	03 Aug 2018 01:00
URI:	http://srodev.sussex.ac.uk/id/eprint/69048

View download statistics for this item

📧 Request an update