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Cranial expression of class 3 secreted semaphorins and their neuropilin receptors

journal contribution
posted on 2023-06-09, 07:07 authored by John K Chilton, Sarah GuthrieSarah Guthrie
The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration. Semaphorins may bind more than one neuropilin or a heterodimer of both, thus a detailed knowledge of their expression patterns may reveal possible cases of redundancy or mutual antagonism. To assess their involvement in cranial development, we cloned fragments of the chick orthologues of Sema3B and Sema3F. We then carried out mRNA in situ hybridisation of all six class 3 semaphorins and both neuropilins in the embryonic chick head. We present evidence for spatiotemporal regulation of these molecules in the brainstem and developing head, including the eye, ear, and branchial arches. These expression patterns provide a basis for functional analysis of semaphorins and neuropilins in the development of axon projections and the morphogenesis of cranial structures. Developmental Dynamics 228:726–733, 2003. © 2003 Wiley-Liss, Inc.

Funding

Human Frontier Science Program

History

Publication status

  • Published

Journal

Developmental Dynamics

ISSN

1058-8388

Publisher

Wiley-Liss Inc

Issue

4

Volume

228

Page range

726-733

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2017-07-11

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