University of Sussex
Browse
9.full.pdf (760.2 kB)

Alternating patterns of cell surface properties and neural crest cell migration during segmentation of the chick hindbrain

Download (760.2 kB)
journal contribution
posted on 2023-06-09, 07:20 authored by Andrew Lumsden, Sarah GuthrieSarah Guthrie
The developing chick hindbrain is transiently divided into a series of repeating units or rhombomeres. Recent work has shown that an alternating periodicity exists both in the cell surface properties of rhombomeres and in the segmental origin of hindbrain neural crest cells. Experiments in which rhombomeres from different axial levels were confronted in the absence of an interrhombomere boundary showed that odd-numbered segments 3 and 5 combined without generating a boundary, as did even-numbered segments 2, 4 and 6. When rhombomeres originating from adjacent positions, or three rhombomeres distant from one another were combined, a new boundary was regenerated. Mapping of the migration pathways of neural crest cells showed that odd-numbered and even-numbered rhombomeres share properties with respect to the production of neural crest cells. In the hindbrain region the neural crest is segregated into streams. Neural crest cells migrating from rhombomeres 1 and 2, rhombomere 4 and rhombomere 6 respectively populate distinct cranial nerve ganglia and branchial arches. In contrast, rhombomeres 3 and 5 are free of neural crest cells.

History

Publication status

  • Published

File Version

  • Published version

Journal

Development

ISSN

0950-1991

Publisher

The company of biologists

Issue

113

Page range

9-15

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-07-21

First Open Access (FOA) Date

2017-07-21

First Compliant Deposit (FCD) Date

2017-07-21

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC