9.full.pdf (760.2 kB)
Alternating patterns of cell surface properties and neural crest cell migration during segmentation of the chick hindbrain
journal contribution
posted on 2023-06-09, 07:20 authored by Andrew Lumsden, Sarah GuthrieSarah GuthrieThe developing chick hindbrain is transiently divided into a series of repeating units or rhombomeres. Recent work has shown that an alternating periodicity exists both in the cell surface properties of rhombomeres and in the segmental origin of hindbrain neural crest cells. Experiments in which rhombomeres from different axial levels were confronted in the absence of an interrhombomere boundary showed that odd-numbered segments 3 and 5 combined without generating a boundary, as did even-numbered segments 2, 4 and 6. When rhombomeres originating from adjacent positions, or three rhombomeres distant from one another were combined, a new boundary was regenerated. Mapping of the migration pathways of neural crest cells showed that odd-numbered and even-numbered rhombomeres share properties with respect to the production of neural crest cells. In the hindbrain region the neural crest is segregated into streams. Neural crest cells migrating from rhombomeres 1 and 2, rhombomere 4 and rhombomere 6 respectively populate distinct cranial nerve ganglia and branchial arches. In contrast, rhombomeres 3 and 5 are free of neural crest cells.
History
Publication status
- Published
File Version
- Published version
Journal
DevelopmentISSN
0950-1991Publisher
The company of biologistsPublisher URL
Issue
113Page range
9-15Department affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-07-21First Open Access (FOA) Date
2017-07-21First Compliant Deposit (FCD) Date
2017-07-21Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC