acsomega paper raysa.pdf (802.95 kB)
Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand
journal contribution
posted on 2023-06-09, 07:28 authored by Raysa Khan, Graham Marsh, Robert Felix, Paul D Kemmitt, Matthias G J Baud, Alessio Ciulli, John SpencerJohn SpencerTC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near gram scale in seven steps with notable improvements in the reported poor yielding last 2 steps enabling this key chemical probe compound to be available for researchers.
Funding
A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASE; G1436; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/M507568/1
History
Publication status
- Published
File Version
- Published version
Journal
ACS OmegaISSN
2470-1343Publisher
American Chemical SocietyExternal DOI
Issue
8Volume
2Page range
4328-4332Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-07-28First Open Access (FOA) Date
2017-08-10First Compliant Deposit (FCD) Date
2017-07-27Usage metrics
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