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Tumor-derived exosomes: potential biomarker or therapeutic target in breast cancer?

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journal contribution
posted on 2023-06-09, 07:38 authored by AmirReza Hesari, Seyed Ali Golrokh Moghadam, AmirShayan Siasi, Gordon FernsGordon Ferns, Faezeh Ghasemi, Amir Avan
Exosomes are released by normal and tumour cells, including those involved in breast cancer, and provide a means of intercellular communications. Exosomes with diameters ranging between 30-150 nm are involved in transferring biological information, via various lipids, proteins, different forms of RNAs, and DNA from one cell to another, and this can result in reprogramming of recipient cell functions. These vesicles are present in all body fluids, e.g., blood plasma/serum, semen, saliva, cerebrospinal fluid, breast milk, and urine. It has been recently reported that these particles are involved in the development and progression of different tumor types, including breast cancer. Furthermore, it has been suggested that exosomes have the potential to be used as drug transporters, or as biomarkers. This review highlights the potential roles of exosomes in normal and breast cancer cells and their potential applications as biomarkers with special focus on their potential applications in treatment of breast cancer.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Cellular Biochemistry

ISSN

0730-2312

Publisher

John Wiley & Sons

Issue

6

Volume

119

Page range

4236-4240

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-08-17

First Open Access (FOA) Date

2018-08-18

First Compliant Deposit (FCD) Date

2017-08-17

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