Tumor.pdf (336.3 kB)
Tumor-derived exosomes: potential biomarker or therapeutic target in breast cancer?
journal contribution
posted on 2023-06-09, 07:38 authored by AmirReza Hesari, Seyed Ali Golrokh Moghadam, AmirShayan Siasi, Gordon FernsGordon Ferns, Faezeh Ghasemi, Amir AvanExosomes are released by normal and tumour cells, including those involved in breast cancer, and provide a means of intercellular communications. Exosomes with diameters ranging between 30-150 nm are involved in transferring biological information, via various lipids, proteins, different forms of RNAs, and DNA from one cell to another, and this can result in reprogramming of recipient cell functions. These vesicles are present in all body fluids, e.g., blood plasma/serum, semen, saliva, cerebrospinal fluid, breast milk, and urine. It has been recently reported that these particles are involved in the development and progression of different tumor types, including breast cancer. Furthermore, it has been suggested that exosomes have the potential to be used as drug transporters, or as biomarkers. This review highlights the potential roles of exosomes in normal and breast cancer cells and their potential applications as biomarkers with special focus on their potential applications in treatment of breast cancer.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Cellular BiochemistryISSN
0730-2312Publisher
John Wiley & SonsExternal DOI
Issue
6Volume
119Page range
4236-4240Department affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-08-17First Open Access (FOA) Date
2018-08-18First Compliant Deposit (FCD) Date
2017-08-17Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC