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Anti-inflammatory effects of eugenol nanoemulsion as a topical delivery system

journal contribution
posted on 2023-06-09, 07:53 authored by Fariba Esmaeili, Saeid Rajabnezhad, Ali Reza Partoazar, Shahram Ejtemaei Mehr, Reza Faridi-Majidi, Mousa Sahebgharani, Leila Syedmoradi, Mohammad Reza Rajabnejad, Amir Amani
Eugenol is the main constituent of clove oil with anti-inflammatory properties. In this work, for the first time, O/W nanoemulsion of eugenol was designed for the evaluation of anti-inflammatory effects as a topical delivery system. Topical formulations containing 1%, 2% and 4% of eugenol as well as a nanoemulsion system containing 4% eugenol and 0.5% piroxicam were prepared. Further to physicochemical examinations, such as determination of particle size, polydispersity index, zeta potential and physical stability, anti-inflammatory activity was examined in carrageenan-induced paw edema in rats. The optimum formulation was found to contain 2% eugenol (oil phase), 14% Tween 20 (surfactant) and 14% isopropyl alcohol (co-surfactant) in water. Nanoemulsion with polydispersity index of 0.3 and median droplet diameter of 24.4?nm (d50) was obtained. Animal studies revealed that the nanoemulsions exhibited significantly improved anti-inflammatory activity after 1.5?h, compared with marketed piroxicam gel. Additionally, it was shown that increasing the concentration of eugenol did not show higher inhibition of inflammation. Also, the nanoemulsion having piroxicam showed less anti-inflammatory properties compared with the nanoemulsion without piroxicam.

History

Publication status

  • Published

Journal

Pharmaceutical Development and Technology

ISSN

1083-7450

Publisher

Taylor & Francis

Issue

7

Volume

21

Page range

887-893

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Pharma Supply Chains and Healthcare Technology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2017-09-12

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