Brydon, Lena, Harrison, Neil A., Walker, Cicely, Steptoe, Andrew and Critchley, Hugo D. (2008) Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biological Psychiatry, 63 (11). pp. 1022-1029. ISSN 1873-2402

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Abstract

BACKGROUND: Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain.

METHODS: We used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design.

RESULTS: Vaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra.

CONCLUSIONS: Our findings provide mechanistic insights into the interaction between inflammation

Item Type:	Article
Additional Information:	This paper is supported by a Wellcome Trust Grant for Prof Hugo Critchley. He has given his permission to put the full published version online as this paper is Open Access as is the policy of Wellcome. If you have any queries regarding this please email him in the first instance H.Critchley@bsms.ac.uk
Keywords:	Cytokines, fMRI, peripheral inflammation, psychomotor slowing, substantia nigra
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience
Subjects:	R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R722 Missionary medicine. Medical missionaries R Medicine > R Medicine (General) > R726.5 Medicine and disease in relation to psychology. Terminal care. R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology
Related URLs:	http://www.ncbi.nlm.nih.gov/pmc/articles...
Depositing User:	Hazelle Woodhurst
Date Deposited:	19 Aug 2011 15:12
Last Modified:	26 Sep 2017 11:10
URI:	http://srodev.sussex.ac.uk/id/eprint/7023
Google Scholar:	40 Citations

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