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CSF β-amyloid and white matter damage -a new perspective on Alzheimer's disease.pdf (361.41 kB)

CSF ß-amyloid and white matter damage: a new perspective on Alzheimer's disease

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posted on 2023-06-21, 06:02 authored by Anna M Pietroboni, Marta Scarioni, Tiziana Carandini, Paola Basilico, Marcello Cadioli, Giovanni Giulietti, Andrea Arighi, Michela Caprioli, Laura Serra, Clara Sina, Chiara Fenoglio, Laura Ghezzi, Georgio G Fumagalli, Milena A De Riz, Alberto Calvi, Fabio Triulzi, Marco Bozzali, Elio Scarpini, Daniela Galimberti
Objective: To assess the connection between amyloid pathology and white matter (WM) macro- and micro-structural damage in demented patients compared with controls. Methods: Eighty-five participants were recruited: 65 with newly diagnosed Alzheimer’s disease (AD), non-AD dementia or mild cognitive impairment (MCI), and 20 age- and sex-matched heatlhy controls. ß-amyloid1-42 (Aß) levels were determined in cerebrospinal fluid (CSF) samples from all patients and 5 controls. Among patients, 42 had pathological CSF Aß levels (Aß+), while 23 had normal CSF Aß levels (Aß-). All participants underwent neurological examination, neuropsychological testing and brain magnetic resonance imaging (MRI). We used T2-weighted scans to quantify white matter (WM) lesion loads (LL), and diffusion weighted images (DWI) to assess their microstructural substrate. Non-parametric statistical tests were used for between-group comparisons and multiple regression analyses. Results: We found an increased WM-LL in Aß(+) compared to both, healthy controls (p=0.003) and Aß(-) patients (p=0.02). Interestingly, CSF Aß concentration was the best predictor patients’ WM-LL (r=-0.30, p<0.05) when using age as a covariate. Lesion apparent diffusion coefficient (ADC) value was higher in all patients than in controls (p=0.0001), and correlated with WM-LL (r=0.41, p=0.001). In Aß(+), WM-LL correlated with WM microstructural damage in the left peritrigonal WM (p<0.0001). Conclusions: WM damage is crucial in Alzheimer’s disease (AD) pathogenesis. The correlation between CSF Aß levels and WM-LL suggests a direct link between amyloid pathology and WM macro- and microstructural damage.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Neurology, Neurosurgery and Psychiatry

ISSN

0022-3050

Publisher

BMJ Publishing Group

Issue

4

Volume

89

Page range

352-357

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-10-02

First Open Access (FOA) Date

2017-10-23

First Compliant Deposit (FCD) Date

2017-10-02

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