Measurement of retinal vessels as a biomarker of cerebrovascular ageing in older HIV positive men compared to controls

Haddow, Lewis, Laverick, Rosanna, Leung, Irene, Post, Frank, Vera, Jaime, Gilson, Richard, Williams, Ian, Boffito, Marta, Sabin, Caroline, Winston, Alan and Peto, Tunde (2018) Measurement of retinal vessels as a biomarker of cerebrovascular ageing in older HIV positive men compared to controls. Journal of Acquired Immune Deficiency Syndromes, 77 (2). pp. 199-205. ISSN 1525-4135

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Background: To compare retinal vascular measurements, biomarkers of cerebral small vessel disease (SVD), in HIV positive men aged 50 years and above with similarly-aged HIV negative men and younger HIV positive men.
Methods: We recruited white, non-diabetic men to a cross-sectional substudy of a larger cohort including three demographically-matched groups. Optic disc centred 45° colour fundus photographs were used to calculate central retinal arterial and venous calibre and the arterial- venous ratio (AVR). We used univariate and multivariable linear regression to compare retinal vessel measurements in the three groups and to identify factors associated with AVR.
Results: All HIV positive men were virologically suppressed. In a multivariable model, study group was not associated with AVR (adjusted β 0.010 for HIV positive men <50 [n=39] compared to HIV positive men aged >50 years [n=120], 95% CI -0.018 to 0.038, p=0.47; adjusted β 0.00002 for HIV negative men >50 years [n=52], 95% CI -0.022 to 0.022, p=0.99). Factors associated with lower AVR were systolic BP (adjusted β -0.009 per +10 mmHg, 95% CI - 0.015 to -0.003, p=0.002), history of stroke or transient ischemic attack (adjusted β -0.070, 95% CI -0.12 to -0.015, p=0.01), and recent recreational drug use (adjusted β -0.037, 95% CI -0.057 to -0.018, p=0.0002).

Conclusion: There were no differences in retinal vascular indices between HIV positive men aged >50 years and HIV negative men aged >50 years or HIV positive men aged <50 years, suggesting that HIV is not associated with an increased burden of cerebral SVD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
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Depositing User: Jaime Vera Rojas
Date Deposited: 27 Oct 2017 09:48
Last Modified: 14 Oct 2018 01:00

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