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Measurement of retinal vessels as a biomarker of cerebrovascular ageing in older HIV positive men compared to controls
journal contribution
posted on 2023-06-09, 08:28 authored by Lewis Haddow, Rosanna Laverick, Irene Leung, Frank Post, Jaime Vera RojasJaime Vera Rojas, Richard Gilson, Ian Williams, Marta Boffito, Caroline Sabin, Alan Winston, Tunde PetoBackground: To compare retinal vascular measurements, biomarkers of cerebral small vessel disease (SVD), in HIV positive men aged 50 years and above with similarly-aged HIV negative men and younger HIV positive men. Methods: We recruited white, non-diabetic men to a cross-sectional substudy of a larger cohort including three demographically-matched groups. Optic disc centred 45° colour fundus photographs were used to calculate central retinal arterial and venous calibre and the arterial- venous ratio (AVR). We used univariate and multivariable linear regression to compare retinal vessel measurements in the three groups and to identify factors associated with AVR. Results: All HIV positive men were virologically suppressed. In a multivariable model, study group was not associated with AVR (adjusted ß 0.010 for HIV positive men <50 [n=39] compared to HIV positive men aged >50 years [n=120], 95% CI -0.018 to 0.038, p=0.47; adjusted ß 0.00002 for HIV negative men >50 years [n=52], 95% CI -0.022 to 0.022, p=0.99). Factors associated with lower AVR were systolic BP (adjusted ß -0.009 per +10 mmHg, 95% CI - 0.015 to -0.003, p=0.002), history of stroke or transient ischemic attack (adjusted ß -0.070, 95% CI -0.12 to -0.015, p=0.01), and recent recreational drug use (adjusted ß -0.037, 95% CI -0.057 to -0.018, p=0.0002). Conclusion: There were no differences in retinal vascular indices between HIV positive men aged >50 years and HIV negative men aged >50 years or HIV positive men aged <50 years, suggesting that HIV is not associated with an increased burden of cerebral SVD.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Acquired Immune Deficiency SyndromesISSN
1525-4135Publisher
Lippincott, Williams & WilkinsExternal DOI
Issue
2Volume
77Page range
199-205Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-10-27First Open Access (FOA) Date
2018-10-14First Compliant Deposit (FCD) Date
2017-10-27Usage metrics
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