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Evolution_of_pulmonary_inflammation_and_nutritional_status_in_infants_and_young_children_with_cystic_fibrosis.pdf (111.82 kB)

Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis

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posted on 2023-06-07, 16:00 authored by Sarath C Ranganathan, Faith Parsons, Catherine Gangell, Siobhan Brennan, Stephen M Stick, Peter D Sly
Introduction Improved nutrition is the major proven benefit of newborn screening programmes for cystic fibrosis (CF) and is associated with better clinical outcomes. It was hypothesised that early pulmonary inflammation and infection in infants with CF is associated with worse nutrition. Methods Weight, height and pulmonary inflammation and infection in bronchoalveolar lavage (BAL) were assessed shortly after diagnosis in infants with CF and again at 1, 2 and 3 years of age. Body mass index (BMI) was expressed as z-scores. Inflammatory cells and cytokines (interleukin 1b (IL-1b), IL-6, IL-8 and tumour necrosis factor a (TNFa)), free neutrophil elastase activity and myeloperoxidase were measured in BAL. Mixed effects modelling was used to assess longitudinal associations between pulmonary inflammation, pulmonary infection (Staphylococcus aureus and Pseudomonas aeruginosa) and BMI z-score after adjusting for potential confounding factors. Results Forty-two infants were studied (16 (38%) male; 39 (93%) pancreatic insufficient); 36 were diagnosed by newborn screening (at median age 4 weeks) and six by early clinical diagnosis (meconium ileus). Thirty-one (74%) received antistaphylococcal antibiotics. More than two-thirds were asymptomatic at each assessment. Mean BMI z-scores were

History

Publication status

  • Published

File Version

  • Published version

Journal

Thorax

ISSN

0040-6376

Publisher

BMJ Publishing Group

Volume

66

Page range

408-413

Department affiliated with

  • Clinical and Experimental Medicine Publications

Notes

IDS Number: 752DD

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-04-03

First Open Access (FOA) Date

2012-04-03

First Compliant Deposit (FCD) Date

2011-07-27

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