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Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism

journal contribution
posted on 2023-06-07, 16:00 authored by Lucia Coppo, Pietro Ghezzi
In?ammation or in?ammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-in?ammatory mediators. However, while several cytokine inhibitors have been approved for drug use in chronic in?ammatory diseases, this has not happened with antioxidant molecules. We outline the complexity of the role protein thiol-disul?de oxidoreduction in the regulation of immunity and in?ammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).

History

Publication status

  • Published

Journal

Biochemical Society Transactions

ISSN

0300-5127

Publisher

Portland Press

Volume

39

Page range

1268-1272

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-04-17

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