Khayyatzadeh, Sayyed Saeid, Vatanparast, Hassanali, Avan, Amir, Bagherniya, Mohammad, Bahrami, Afsane, Kiani, Mohammad Ali, Bahrami-Taghanaki, Hamidreza, Ferns, Gordon A and Ghayour-Mobarhan, Majid (2017) Serum transaminase concentrations and the presence of irritable bowel syndrome are associated with serum 25-hydroxy vitamin D concentrations in adolescent girls who are overweight and obese. Annals of Nutrition and Metabolism, 71 (3-4). pp. 234-241. ISSN 0250-6807

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Abstract

Vitamin D deficiency has become en- demic globally and its etiology is complex. Few studies have investigated the determinants of serum 25-hydroxy vitamin D (25-OH D). The aim of this study was to investigate the as- sociation between lifestyle patterns, liver functional tests (LFTs), and the presence of irritable bowel syndrome (IBS) with serum 25-OH D in apparently healthy girls. Methods:
This cross-sectional study was undertaken in 965 adolescent girls aged 12–18 years. IBS was diagnosed using the Rome III questionnaire. An electrochemiluminescence method was used to measure serum 25-OH D. LFTs were measured using commercial kits and an auto analyzer. Linear regression and univariate analyses were performed to determine the asso- ciation between continuous and categorical variables with serum 25-OH D respectively. Results: Serum 25-OH D was significantly higher in normal weight subjects compared to either overweight or obese subjects (9.5 ± 7.02 vs. 7.9 ± 5.7 ng/mL, p = 0.03). Physical activity level was positively associ- ated with serum 25-OH D in overweight and obese sub- jects (β = 0.15, p < 0.05). An inverse relationship was foundbetween the presence of IBS and 25-OH D in both normal (β = –1.95, p < 0.05), overweight and obese subjects (β = –1.83, p < 0.05). Serum alanine transaminase (ALT; β = –0.19, p < 0.05) and aspartate transaminase (β = –0.17, p < 0.05) were inversely associated with serum 25-OH in overweight and obese subjects. Conclusions: Individuals with IBS had significantly lower serum 25-OH D concentrations. In addi- tion, there was an inverse association between serum ALT and 25-OH D. Prospective studies, and perhaps intervention- al trials, will be required to clarify these associations.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Division of Medical Education
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Gordon Ferns
Date Deposited:	28 Nov 2017 09:14
Last Modified:	28 Nov 2017 09:15
URI:	http://srodev.sussex.ac.uk/id/eprint/71615

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