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Pre-treatment waking cortisol response and vulnerability to interferon a induced depression
journal contribution
posted on 2023-06-07, 16:04 authored by Jessica EcclesJessica Eccles, Camille Lallemant, Farrah Mushtaq, Matthew Greenwood, Majella Keller, Bruno Golding, Jeremy Tibble, Inam Haq, Richard WhaleDepressive disorder is a common consequence of interferon a treatment. An understanding of the aetiological processes involved is evolving. HPA axis abnormalities are clearly described in community depressive disorder and represent vulnerability to depression development. We explored whether pre-treatment HPA axis abnormalities influence depression emergence during interferon a treatment. We examined waking HPA axis response via salivary cortisol sampling in 44 non-depressed, chronic hepatitis C infected patients due to commence standard interferon a treatment. Hamilton depression scales and the structured clinical interview for DSM-IV major depressive disorder status were administered monthly during treatment. Major depressive disorder developed in 26 of 44 subjects during interferon-a treatment. The pre-treatment waking cortisol response over 1h was significantly greater in the subsequent switch to depression group (F=4.23, p=0.046). The waking cortisol response pre-treatment with interferon a appears greater in those subsequently switching to depressive disorder during treatment. This waking response may join other vulnerability factors for depression emergence in this group. This model could prove a valuable tool in understanding non-iatrogenic depressive disorder in the general population and notably the role of cytokines.
History
Publication status
- Published
Journal
European NeuropsychopharmacologyISSN
0924-977XPublisher
ElsevierExternal DOI
Issue
12Volume
22Page range
892-896Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-07-31Usage metrics
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