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Thye, Thorsten, Vannberg, Fredrik O., Wong, Sunny H., Owusu-Dabo, Ellis, Osei, Ivy, Gyapong, John, Sirugo, Giorgio, Sisay-Joof, Fatou, Enimil, Anthony, Chinbuah, Margaret A., Floyd, Sian, Warndorff, David K., Sichali, Lifted, Malema, Simon, Crampin, Amelia C., Ngwira, Bagrey, Teo, Yik Y., Small, Kerrin, Rockett, Kirk, Kwiatkowski, Dominic, Fine, Paul E., Hill, Philip C., Newport, Melanie J., Lienhardt, Christian, Adegbola, Richard A., Corrah, Tumani, Ziegler, Andreas, Morris, Andrew P., Meyer, Christian G., Horstmann, Rolf D. and Hill, Adrian V. S. (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics, 42 (9). pp. 739-741. ISSN 1061-4036
Full text not available from this repository.Abstract
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Global Health and Infection |
| Subjects: | Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics |
| Depositing User: | Grecia GarciaGarcia |
| Date Deposited: | 16 Aug 2011 09:27 |
| Last Modified: | 21 Sep 2017 11:49 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/7221 |
| Google Scholar: | 31 Citations |