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Fury_2014_J._Phys.__Conf._Ser._498_012002.pdf (3.8 MB)

Laser vibrometry characterisation of a microfluidic lab-on-a-chip device: a preliminary investigation

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posted on 2023-06-21, 06:02 authored by C Fury, P N Gélat, P H Jones, G Memoli
Since their original inception as ultrasound contrast agents, potential applications of microbubbles have evolved to encompass molecular imaging and targeted drug delivery. As these areas develop, so does the need to understand the mechanisms behind the interaction of microbubbles both with biological tissue and with other microbubbles. There is therefore a metrological requirement to develop a controlled environment in which to study these processes. Presented here is the design and characterisation of such a system, which consists of a microfluidic chip, specifically developed for manipulating microbubbles using both optical and acoustic trapping. A laser vibrometer is used to observe the coupling of acoustic energy into the chip from a piezoelectric transducer bonded to the surface. Measurement of the velocity of surface waves on the chip is investigated as a potential method for inferring the nature of the acoustic fields excited within the liquid medium of the device. Comparison of measured surface wavelengths with wave types suggests the observation of anti-symmetric Lamb or Love-Kirchhoff waves. Further visual confirmation of the acoustic fields through bubble aggregation highlights differences between the model and experimental results in predicting the position of acoustic pressure nodes in relation to excitation frequency.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Physics: Conference Series

ISSN

1742-6588

Publisher

IOP Publishing

Issue

1

Volume

498

Page range

012002

Department affiliated with

  • Informatics Publications

Research groups affiliated with

  • Creative Technology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-02

First Open Access (FOA) Date

2018-01-02

First Compliant Deposit (FCD) Date

2018-01-02

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