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Kusunoki, Makoto, Sigala, Natasha, Gaffan, David and Duncan, John (2009) Detection of fixed and variable targets in the monkey prefrontal cortex. Cerebral Cortex, 19 (11). pp. 2522-2534. ISSN 1047-3211
Full text not available from this repository.Abstract
Behavioral significance is commonly coded by prefrontal neurons. The significance of a stimulus can be fixed through experience; in complex behavior, however, significance commonly changes with short-term context. To compare these cases, we trained monkeys in 2 versions of visual target detection. In both tasks, animals monitored a series of pictures, making a go response (saccade) at the offset of a specified target picture. In one version, based on "consistent mapping" in human visual search, target and nontarget pictures were fixed throughout training. In the other, based on "varied mapping," a cue at trial onset defined a new target. Building up over the first 1 s following this cue, many cells coded short-term context (cue/target identity) for the current trial. Thereafter, the cell population showed similar coding of behavioral significance in the 2 tasks, with selective early response to targets, and later, sustained activity coding target or nontarget until response. This population similarity was seen despite quite different activity in the 2 tasks for many single cells. At the population level, the results suggest similar prefrontal coding of fixed and short-term behavioral significance
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders |
| Depositing User: | Grecia GarciaGarcia |
| Date Deposited: | 22 Aug 2011 10:33 |
| Last Modified: | 26 Sep 2017 11:55 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/7280 |
| Google Scholar: | 8 Citations |