Sood, Vikas, Rathore, Anurag, Husain, Sajid, Khan, Sohrab, Patra, Shruti, Shankar, Vijay, Kumar, Harsh, Rani, Neha, Bano, Aalia S, Neogi, Ujjwal, Ramachandran, V G and Banerjea, Akhil C (2008) Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV. Indian Journal of Biochemistry and Biophysics, 45 (3). pp. 141-148. ISSN 0301-1208

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Abstract

A multitude of host and viral factors play critical role in susceptibility to HIV-1 infection and its subsequent progression to AIDS. Various host factors involved in HIV-1 infection include the chemokine receptors CCR5, CX3CR1, their ligands, RANTES, SDF-1 and cytokines like IL-10, IL-4, among others. The CCR5Δ32 allele is the most important genetic factor known to confer resistance to HIV-1 infection. However, other mutations in CCR5, CX3CR1 and SDF-1 have also been identified in Indian population. Polymorphisms in DC-SIGN, MHC class-I and II molecules are also known to affect HIV-1 progression. These polymorphisms can be utilized as genetic markers for evaluating disease progression and developing effective therapeutics. The review also describes the development of anti-viral therapy, involving the use of catalytic nucleic acids like DNA-enzymes and ribozymes and the expression of ribozymes and si-RNA using lentiviral vectors for stem cell based anti-HIV therapy.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User:	Sandy Gray
Date Deposited:	02 Mar 2018 10:40
Last Modified:	02 Mar 2018 10:40
URI:	http://srodev.sussex.ac.uk/id/eprint/74165

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