Tools
Tools
Jenkins, V.A., Shilling, V, Deutsch, G., Bloomfield, D., Morris, R., Allan, S., Bishop, H., Hodson, N., Mitra, S., Sadler, G., Shah, E., Stein, R., Whitehead, S. and Winstanley, J. (2006) A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer. British Journal of Cancer, 94 (6). pp. 828-34. ISSN 0007-0920
Full text not available from this repository.Abstract
The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis found no significant interactions or main effect of group after controlling for age and intelligence. Using a calculation to examine performance at an individual level, reliable decline on multiple tasks was seen in 20% of chemotherapy patients, 26% of nonchemotherapy patients and 18% of controls at T2 (18%, 14 and 11%, respectively, at T3). Patients who had experienced a treatment-induced menopause were more likely to show reliable decline on multiple measures at T2 (OR=2.6, 95% confidence interval (CI) 0.823-8.266 P=0.086). Psychological distress, quality of life measures and self-reported cognitive failures did not impact on objective tests of cognitive function, but were significantly associated with each other. The results show that a few women experienced objective measurable change in their concentration and memory following standard adjuvant therapy, but the majority were either unaffected or even improve over time.
| Item Type: | Article |
|---|---|
| Additional Information: | 0007-0920 (Print) Journal Article Research Support, Non-U.S. Gov't |
| Keywords: | Adult Aged Antineoplastic Agents, Hormonal/*adverse effects/therapeutic use Breast Neoplasms/*drug therapy/*psychology/radiotherapy Case-Control Studies Chemotherapy, Adjuvant/adverse effects Cognition Disorders/*etiology Female Humans Intelligence Memory Disorders/etiology Middle Aged Neuropsychological Tests Prospective Studies Quality of Life Radiotherapy, Adjuvant/adverse effects Stress, Psychological Endocrine Treatment Cognitive Dysfunction |
| Schools and Departments: | Brighton and Sussex Medical School > Sussex Health Outcomes Research & Education in Cancer (SHORE-C) |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology > BF0309 Consciousness. Cognition Including learning, attention, comprehension, memory, imagination, genius, intelligence, thought and thinking, psycholinguistics, mental fatigue R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens R Medicine > RG Gynecology and obstetrics > RG0491 Diseases of the breast R Medicine > RM Therapeutics. Pharmacology > RM0260 Chemotherapy |
| Depositing User: | Tracy Woodcock |
| Date Deposited: | 09 Nov 2011 10:20 |
| Last Modified: | 16 Aug 2016 10:23 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/7433 |
| Google Scholar: | 145 Citations |