Neurosyphilis in patients with HIV

Hobbs, Emily, Vera, Jaime H, Marks, Michael, Barritt, Andrew William, Ridha, Basil H and Lawrence, David (2018) Neurosyphilis in patients with HIV. Practical Neurology. pp. 1-9. ISSN 1474-7758

[img] PDF - Accepted Version
Restricted to SRO admin only until 24 February 2019.

Download (373kB)
[img] PDF - Published Version
Restricted to SRO admin only

Download (480kB)


Syphilis is a resurgent sexually transmitted infection in the UK that is disproportionately diagnosed in patients living with HIV, particularly in men who have sex with men. Syphilis appears to present differently in patients with HIV, particularly in those with severe immunosuppression. Progression to neurosyphilis is more common in HIV coinfection and can be asymptomatic, often for several years. The presentations of neurosyphilis vary but can include meningitis, meningovascular disease, general paresis and tabes dorsalis. There is debate about the circumstances in which to perform a lumbar puncture, and the current gold standard diagnostics have inadequate sensitivity. We recommend a pragmatic approach to lumbar punctures, interpreting investigations and deciding when to consider treatment with a neuropenetrative antibiotic regimen.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
Depositing User: Jaime Vera Rojas
Date Deposited: 20 Mar 2018 15:15
Last Modified: 21 Mar 2018 09:11

View download statistics for this item

📧 Request an update