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Neural circuits of eating behaviour: opportunities for therapeutic development
Understanding of the neural and physiological substrates of hunger and satiety has increased rapidly over the last three decades, and pharmacological targets have already been identified for the treatment of obesity that has moved from pre-clinical screening to therapies approved by regulatory authorities. Initially, this review describes the way in which physiological signals of energy availability interact with hedonic and rewarding properties of food to modulate the neural circuitry that supports eating behaviour. This is followed by a brief account of current and promising targets for drug development and a review of the wide range of preclinical paradigms that model important influences on human eating behaviour, and can be used to guide early stages of the drug development process.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of PsychopharmacologyISSN
0269-8811Publisher
SAGE PublicationsExternal DOI
Issue
11Volume
31Page range
1388-1402Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-04-05First Open Access (FOA) Date
2018-04-05First Compliant Deposit (FCD) Date
2018-04-04Usage metrics
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