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Neural circuits of eating behaviour: opportunities for therapeutic development

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posted on 2023-06-09, 12:39 authored by Pete CliftonPete Clifton
Understanding of the neural and physiological substrates of hunger and satiety has increased rapidly over the last three decades, and pharmacological targets have already been identified for the treatment of obesity that has moved from pre-clinical screening to therapies approved by regulatory authorities. Initially, this review describes the way in which physiological signals of energy availability interact with hedonic and rewarding properties of food to modulate the neural circuitry that supports eating behaviour. This is followed by a brief account of current and promising targets for drug development and a review of the wide range of preclinical paradigms that model important influences on human eating behaviour, and can be used to guide early stages of the drug development process.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Psychopharmacology

ISSN

0269-8811

Publisher

SAGE Publications

Issue

11

Volume

31

Page range

1388-1402

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-04-05

First Open Access (FOA) Date

2018-04-05

First Compliant Deposit (FCD) Date

2018-04-04

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