Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: a population-based study

Shafiee, Mojtaba, Ahmadnezhad, Masha, Tayefi, Maryam, Arekhi, Soheil, Vatanparast, Hassanali, Esmaeli, Habibollah, Moohebati, Mohsen, Ferns, Gordon A, Mokhbar, Naghmeh, Arefhosseini, Seyed Rafie and Ghayour-Mobarhan, Majid (2018) Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: a population-based study. Journal of Affective Disorders, 238. pp. 491-498. ISSN 0165-0327

[img] PDF - Accepted Version
Available under License Creative Commons Attribution-NonCommercial No Derivatives.

Download (259kB)
[img] PDF - Supplemental Material
Restricted to SRO admin only

Download (45kB)
[img] PDF - Supplemental Material
Restricted to SRO admin only

Download (45kB)

Abstract

Background: Depression and anxiety are significantly associated with systemic inflammation. Moreover, oxidative stress resulting from a disturbance in the prooxidant-antioxidant balance is linked to inflammation-related conditions. Therefore, depression/anxiety symptoms may also be associated with oxidative stress.
Objective: To examine the association between depression/anxiety symptoms and serum prooxidant-antioxidant balance (PAB) in adults who participated in a large population-based, cross-sectional study.
Methods: Serum PAB values were measured in 7,516 participants (62% females and 38% males) aged 35–65 years, enrolled in a population-based cohort study. Beck Depression and Anxiety Inventories were used to evaluate symptoms of depression and anxiety. Multinomial logistic regression was used to examine the effect of confounders on the status of serum PAB change.
Results: Among men, serum PAB values were increased incrementally from 1.55±0.47 to 1.59±0.47, 1.69±0.38, and 1.68±0.38 in the no or minimal, mild, moderate and severe depression groups, respectively (P trend<0.001). Serum PAB values also increased significantly across these four corresponding groups among women [1.70±0.45, 1.73±0.44, 1.75±0.44, and 1.76±0.40, (P trend=0.005)]. About anxiety, serum PAB values increased significantly across the four groups in men (P trend=0.02) but not in women (P trend=0.2). The adjusted odds ratios for serum PAB values among men with severe depression and anxiety symptoms were 1.75 and 1.27, respectively. Moreover, the adjusted odds ratios for serum PAB values among women with severe depression and anxiety symptoms were 1.40 and 1.17, respectively.
Conclusion: Symptoms of depression and anxiety appear to be associated with higher degrees of oxidative stress, expressed by higher serum PAB values.

Item Type: Article
Keywords: Depression; Anxiety; Prooxidant-antioxidant balance; Oxidative stress
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 05 Jun 2018 08:28
Last Modified: 27 Jun 2018 14:56
URI: http://srodev.sussex.ac.uk/id/eprint/76217

View download statistics for this item

📧 Request an update