oe-21-4-5005.pdf (1.11 MB)
Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector
journal contribution
posted on 2023-06-09, 13:34 authored by Nathan R Gemmell, Aongus McCarthy, Baochang Liu, Michael G Tanner, Sander D Dorenbos, Valery Zwiller, Michael S Patterson, Gerald S Buller, Brian C Wilson, Robert H HadfieldDirect monitoring of singlet oxygen (1O2) luminescence is a particularly challenging infrared photodetection problem. 1O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record 1O2 luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the 1O2 signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of 1O2 luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.
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Publication status
- Published
File Version
- Published version
Journal
Optics ExpressISSN
1094-4087Publisher
Optical Society of AmericaExternal DOI
Issue
4Volume
21Page range
5005Department affiliated with
- Engineering and Design Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-05-30First Open Access (FOA) Date
2018-05-31First Compliant Deposit (FCD) Date
2018-05-31Usage metrics
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