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Enhanced optics for time-resolved singlet oxygen luminescence detection

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Version 2 2023-06-12, 07:22
Version 1 2023-06-09, 13:35
journal contribution
posted on 2023-06-12, 07:22 authored by Konstantinos Tsimvrakidis, Nathan R Gemmell, Kleanthis Erotokritou, Shigehito Miki, Masahiro Yabuno, Taro Yamashita, Hirotaka Terai, Robert Hadfield
Singlet oxygen luminescence dosimetry (SOLD) is a highly promising direct monitoring method for photodynamic therapy (PDT) in the treatment of cancer. Early SOLD systems have been hampered by inefficient excitation, poor optical collection and immature infrared single photon detection technology. We report carefully engineered improvements addressing all of these deficiencies. We use a supercontinuum source with a tunable filter to precisely target the peak absorption wavelength of the chosen photosensitizer; we have designed a compact and versatile optical package for precise alignment; we have successfully employed state-of-the-art superconducting photon counting technologies. Through these improvements, we can achieve real-time histogram acquisition from a photosensitizer in solution test sample. This setup opens the pathway to physiological SOLD studies for PDT dosimetry.

History

Publication status

  • Published

File Version

  • Published version

Journal

IEEE Journal of Selected Topics in Quantum Electronics

ISSN

1077-260X

Publisher

Institute of Electrical and Electronics Engineers

Issue

1

Volume

25

Page range

1-7

Department affiliated with

  • Engineering and Design Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-05-31

First Open Access (FOA) Date

2018-06-01

First Compliant Deposit (FCD) Date

2018-06-01

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