NEJM letter 2017.pdf (75.4 kB)
[Correspondence] Clonal hematopoiesis and atherosclerosis
journal contribution
posted on 2023-06-09, 13:37 authored by Rupert Phillips, Sabah Chaudry, Timothy ChevassutTimothy ChevassutJaiswal et al. report the results of four case–control studies that confirm a near doubling in the risk of coronary heart disease in patients with CHIP,1 a finding that was first reported in the Journal in 2014.2 The authors postulate that two mechanisms may be involved: the promotion of inflammatory responses, as supported in a study involving Tet2 knockout mice, and an increase in the number of myeloid cells, a finding that appears to be more relevant for patients with JAK2 mutations, which confer a much larger risk than the more common DNMT3A, TET2, and ASXL1 mutations, in which blood counts remain normal. However, the authors do not provide data relating to red-cell distribution width, which is the only blood-cell index that has been shown to have a significant association with CHIP2 and which has been associated with an unexplained increase in all-cause mortality in an aging population. 3,4 In understanding how CHIP promotes atherosclerosis, it is important to explore the causal relationship between clonal hematopoiesis and red-cell anisocytosis to determine whether these are independent or associated risk factors for cardiovascular disease.
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Publication status
- Published
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- Published version
Journal
New England Journal of MedicineISSN
0028-4793Publisher
Massachusetts Medical SocietyExternal DOI
Issue
14Volume
377Page range
1400-1402Department affiliated with
- BSMS Publications
Research groups affiliated with
- Haematology Research Group Publications
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- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-06-04First Open Access (FOA) Date
2018-06-04First Compliant Deposit (FCD) Date
2018-06-01Usage metrics
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