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BET inhibition autophagy paper.pdf (3.89 MB)

BET inhibition suppresses S100A8 and S100A9 expression in acute myeloid leukemia cells and synergises with daunorubicin in causing cell death

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posted on 2023-06-09, 13:37 authored by Helen Stewart, Sabah Chaudry, Asante Crichlow, Freya Luling Feilding, Timothy ChevassutTimothy Chevassut
S100A8 and S100A9 are both members of the S100 family and have been shown to play roles in myeloid differentiation, autophagy, apoptosis, and chemotherapy resistance. In this study we demonstrate that the BET-bromodomain inhibitor JQ1 causes rapid suppression of S100A8 and S100A9 mRNA and protein in a reversible manner. In addition, we show that JQ1 synergises with daunorubicin in causing AML cell death. Daunorubicin alone causes a dose- and time-dependent increase in S100A8 and S100A9 protein levels in AML cell lines which is overcome by cotreatment with JQ1. This suggests that JQ1 synergises with daunorubicin in causing apoptosis via suppression of S100A8 and S100A9 levels.

History

Publication status

  • Published

File Version

  • Published version

Journal

Bone Marrow Research

ISSN

2090-2999

Publisher

Hindawi Publishing Corporation

Issue

574295

Volume

2018

Department affiliated with

  • BSMS Publications

Research groups affiliated with

  • Haematology Research Group Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-06-04

First Open Access (FOA) Date

2018-06-04

First Compliant Deposit (FCD) Date

2018-06-01

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