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Adjusting to a new home: Mycobacterium tuberculosis gene expression in response to an intracellular lifestyle.

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posted on 2023-06-07, 16:22 authored by Richard W Stokes, Simon WaddellSimon Waddell
Mycobacterium tuberculosis remains the most significant single species of bacteria causing disease in mankind. The ability of M. tuberculosis to survive and replicate within host macrophages is a pivotal step in its pathogenesis. Understanding the microenvironments that M. tuberculosis encounters within the macrophage and the adaptations that the bacterium undergoes to facilitate its survival will lead to insights into possible therapeutic targets for improved treatment of tuberculosis. This is urgently needed with the emergence of multi- and extensively drug resistant strains of M. tuberculosis. Significant advances have been made in understanding the macrophage response on encountering M. tuberculosis. Complementary information is also accumulating regarding the counter responses of M. tuberculosis during the various stages of its interactions with the host. As such, a picture is emerging delineating the gene expression of intracellular M. tuberculosis at different stages of the interaction with macrophages.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Future Microbiology

ISSN

1746-0921

Publisher

Future Medicine

Issue

10

Volume

4

Page range

1317-1335

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-01-04

First Open Access (FOA) Date

2017-01-23

First Compliant Deposit (FCD) Date

2017-01-23

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