Pathan, Nazima, Franklin, Joanne L, Eleftherohorinou, Hariklia, Wright, Victoria J, Hemingway, Cheryl A, Waddell, Simon J, Griffiths, Michael, Dennis, Jayne L, Relman, David A, Harding, Sian E and Levin, Michael (2011) Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase. Critical Care Medicine, 39 (7). pp. 1692-1711. ISSN 0090-3493
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Abstract
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity. Dysregulation of the p38 mitogen-activated protein kinase pathway in meningococcal septicemia suggests that this pathway may be an important target for novel therapies to reverse myocardial dysfunction in patients with meningococcal septic shock who are not responsive to inotropic support.
Item Type: | Article |
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Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Global Health and Infection |
Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology > QR0180 Immunology R Medicine > RJ Pediatrics |
Depositing User: | Simon Waddell |
Date Deposited: | 17 Jul 2012 13:42 |
Last Modified: | 22 Sep 2017 11:17 |
URI: | http://srodev.sussex.ac.uk/id/eprint/7642 |
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