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Toll-like receptors signaling pathways as a potential therapeutic target in cardiovascular disease

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posted on 2023-06-20, 14:17 authored by Seyed Mostafa Parizadeh, Maryam Ghandehar, Motahareh Heydari-Majd, Sima Seifi, Ramin Mardani, Seyed Mohamahdreza Parizadeh, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns, Seyed Mahdi Hassanian, Amir Avan
Cardiovascular disease (CVD) is one of the most important causes of morbidity and mortality, and associated with an important economic burden globally. Over the last decade, the prevalence of CVD has been rising globally, and is now associated with millions of death annually in both developed and developing countries. There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors (TLRs) and their down-stream signaling pathways play an important role in the immune system. Recent studies have suggested that the TLRs are involved in atherogenesis, including stroke, myocardial infarction, ischemia-reperfusion injury, cardiac remodeling and development of heart failure (HF). In this review we have summarized the recent studies investigating the role of TLRs in CVD and the potential for using TLRs signaling pathways as a therapeutic target in CVD.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Pharmaceutical Design

ISSN

1381-6128

Publisher

Bentham Science Publishers

Issue

17

Volume

24

Page range

1887-1898

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-06-12

First Open Access (FOA) Date

2019-10-03

First Compliant Deposit (FCD) Date

2018-06-12

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