Toll-like receptors signaling pathways as a potential therapeutic target in cardiovascular disease

Parizadeh, Seyed Mostafa, Ghandehar, Maryam, Heydari-Majd, Motahareh, Seifi, Sima, Mardani, Ramin, Parizadeh, Seyed Mohamahdreza, Ghayour-Mobarhan, Majid, Ferns, Gordon, Hassanian, Seyed Mahdi and Avan, Amir (2018) Toll-like receptors signaling pathways as a potential therapeutic target in cardiovascular disease. Current Pharmaceutical Design, 24 (17). ISSN 1381-6128 (Accepted)

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Abstract

Cardiovascular disease (CVD) is one of the most important causes of morbidity and mortality, and associated with an important economic burden globally. Over the last decade, the prevalence of CVD has been rising globally, and is now associated with millions of death annually in both developed and developing countries. There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors (TLRs) and their down-stream signaling pathways play an important role in the immune system. Recent studies have suggested that the TLRs are involved in atherogenesis, including stroke, myocardial infarction, ischemia-reperfusion injury, cardiac remodeling and development of heart failure (HF). In this review we have summarized the recent studies investigating the role of TLRs in CVD and the potential for using TLRs signaling pathways as a therapeutic target in CVD.

Item Type: Article
Keywords: cardiovascular disease, immune system, Toll-like receptors, signaling pathway
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 12 Jun 2018 14:36
Last Modified: 29 Nov 2018 16:06
URI: http://srodev.sussex.ac.uk/id/eprint/76427

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