CSF β-amyloid predicts prognosis in patients with multiple sclerosis

Pietroboni, Anna, Caprioli, Michela, Carandini, Tiziana, Scarioni, Marta, Ghezzi, Laura, Arighi, Andrea, Cioffi, Sara, Cinnante, Claudia, Fenoglio, Chiara, Oldoni, Emmanuela, Basilico, Paola, Fumagalli, Giorgio, Colombi, Annalisa, Giulietti, Giovanni, Serra, Laura, Triulzi, Fabio, Bozzali, Marco, Scarpini, Elio and Galimberti, Daniela (2018) CSF β-amyloid predicts prognosis in patients with multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585

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Abstract

Background: The importance of predicting disease progression in multiple sclerosis (MS) has increasingly been recognised, hence reliable biomarkers are needed.
Objectives: To investigate the prognostic role of cerebrospinal fluid (CSF) Amyloid beta1-42 (A) levels by the determination of a cut-off value to classify patients in slow and fast progressors. To evaluate possible association with white (WM) and grey matter (GM) damage at early disease stages.
Methods: Sixty patients were recruited and followed-up for three to five years. Patients underwent clinical assessment, CSF analysis to determine Aβ levels, and brain MRI (at baseline and after 1 year). T1-weighted volumes were calculated. T2-weighted scans were used to quantify WM lesion loads.
Results: Lower CSF Aβ levels were observed in patients with a worse follow-up EDSS (r=−0.65, p<0.001). The multiple regression analysis confirmed CSF Aβ concentration as a predictor of patients’ EDSS increase (r=−0.59, p<0.0001). Generating a receiver operator characteristic curve, a cut-off value of 813 pg/ml was determined as the threshold able to identify patients with worse prognosis (95%CI 0.690-0.933, p=0.0001). No differences in CSF tau and NfL levels were observed (p>0.05).
Conclusions: Low CSF Aβ levels may represent a predictive biomarker of disease progression in MS.

Item Type: Article
Keywords: Biomarkers; MRI; Multiple Sclerosis
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 24 Jul 2018 09:32
Last Modified: 26 Oct 2018 14:09
URI: http://srodev.sussex.ac.uk/id/eprint/77336

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