Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer

Moradi-Marjaneh, Reyhaneh, Khazaei, Majid, Seifi, Sima, Hassanian, Seyed Mahdi, Ferns, Gordon A and Avan, Amir (2018) Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer. Current Pharmaceutical Design, 24 (23). pp. 2710-2718. ISSN 1381-6128

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Abstract

Inter-individual differences in drug response are an important cause of failure in anticancer treatment and adverse drug events in cancer patients. Gene polymorphisms related to these outcomes have been investigated in an effort to find new genetic biomarkers to predict toxicity and response to anticancer drugs. Evaluating the value single nucleotide polymorphisms (SNPs) in the genes involved in transportation, activation and metabolism of anticancer drugs provides a promising approach to select the appropriate therapeutic regimes with at least adverse reactions. This review summarizes the current knowledge about the relationship between of SNPs involved in the transportation, activation and metabolism of anticancer drugs and treatment outcomes in colorectal cancer (CRC) patients.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 06 Aug 2018 10:13
Last Modified: 31 Oct 2018 09:34
URI: http://srodev.sussex.ac.uk/id/eprint/77537

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