accepted Epigenetic drug therapy in the treatment of colorectal cancer.pdf (978.98 kB)
Epigenetic drug therapy in the treatment of colorectal cancer
journal contribution
posted on 2023-06-09, 14:22 authored by Seyed Mostafa Parizadeh, Reza Jafarzadeh Esfehani, Maryam Ghandehari, Sima Seifi, Seyed Mohammad Reza Parizadeh, Mehrdad Moetamani-Ahmadi, Seyed Mahdi Hassanian, Majid Khazaei, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns, Amir AvanColorectal cancer (CRC) is one of the most common cancers with a high rate of morbidity and mortality worldwide. The incidence of CRC is similar in men and women but is distributed uniformly globally. It has been demonstrated that epigenetic alterations which may cause changes in the expression of microRNA, DNA methylation and histone acetylation that results in inheritable modifications in gene expression in colorectal epithelial cells, plays a crucial role in the development of CRC. Recently, targeting epigenetic modification has emerged as a potentially important treatment approach in CRC. The US Food and Drug Association has approved the use of some epigenetic drugs that may be able to inhibit or reverse these alterations and also enhance sensitivity to chemotherapeutic agents and radiotherapy in CRC. In this review we have summarized the recent pre-clinical and clinical trial studies investigating the therapeutic value of using epigenetic drugs as novel therapeutic approach in CRC treatment. Keywords: epigenetic, colorectal cancer, drug, DNA methylation, histone acetylation
History
Publication status
- Published
File Version
- Accepted version
Journal
Current Pharmaceutical DesignISSN
1381-6128Publisher
Bentham Science PublishersIssue
23Volume
24Page range
2701-2709Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-08-06First Open Access (FOA) Date
2019-10-24First Compliant Deposit (FCD) Date
2018-08-03Usage metrics
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