Retroviral pseudotypes - from scientific tools to clinical utility

Temperton, Nigel J, Wright, Edward and Scott, Simon D (2015) Retroviral pseudotypes - from scientific tools to clinical utility. In: Encyclopedia of life sciences. John Wiley & Sons, pp. 1-11. ISBN 9780470015902

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Retroviral pseudotypes are important research and diagnostic tools for basic and clinical virology studies, facilitating the detailed investigation of individual genes, cellular receptors, antibody responses, serosurveillance and antiviral therapies. Importantly, pseudotypes enable the study of highly pathogenic viruses, without the need for high containment. Their use as gene therapy vectors is widely documented, but other uses, once less well known, are becoming more prominent. The substitution of envelope proteins expressed on the virion surface enables pseudotypes to be employed as surrogates for wildtype viruses in antibody neutralisation or antiviral screening assays and for the study of cell–virus receptor interactions. In addition, they are increasingly being utilised as vaccine immunogens, expressing the antigen either on the particle surface or as a transfer gene for cellular expression. These studies demonstrate the potential for using pseudotypes for both scientific and clinical applications.

Item Type: Book Section
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QR Microbiology > QR0355 Virology
Depositing User: Edward Wright
Date Deposited: 14 Aug 2018 10:04
Last Modified: 16 Aug 2018 08:00
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