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Binge drinking is associated with attenuated frontal and parietal activation during successful response inhibition in fearful context

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posted on 2023-06-09, 14:39 authored by Aleksandra Herman, Hugo CritchleyHugo Critchley, Dora Duka
Binge drinking is associated with increased impulsivity and altered emotional processing. The current study investigated, in a group of university students who differed in their level of binge drinking, whether the ability to inhibit a pre-potent response and to delay gratification is disrupted in the presence of emotional context. We further tested whether functional connectivity within intrinsic resting-state networks was associated with alcohol use. Higher incidence of binge drinking was associated with enhanced activation of the lateral occipital cortex, angular gyrus, the left frontal pole during successful response inhibition irrespective of emotional context. This observation suggests a compensatory mechanism. However, higher binge drinking attenuated frontal and parietal activation during successful response inhibition within a fearful context, indicating the selective emotional facilitation of inhibitory control. Similarly, higher binge drinking was associated with attenuated frontopolar activation when choosing a delayed reward over an immediate reward within the fearful, relative to the neutral, context. Resting-state functional data analysis revealed that binge drinking decreased coupling between right supramarginal gyrus and Ventral Attention Network, indicating alcohol-associated disruption of functional connectivity within brain substrates directing attention. Together, our results suggest that binge drinking makes response inhibition more effortful, yet emotional (more arousing) contexts may mitigate this; disrupted functional connectivity between regions underlying adaptive attentional control, is a likely mechanism underlying these response inhibition effects associated with binge drinking.

Funding

European Union's Horizon 2020; 668863-SyBil-AA

Sussex Neuroscience

History

Publication status

  • Published

File Version

  • Accepted version

Journal

European Journal of Neuroscience

ISSN

0953-816X

Publisher

Wiley

Department affiliated with

  • BSMS Neuroscience Publications

Research groups affiliated with

  • Sussex Addiction Research and Intervention Centre (SARIC) Publications
  • Sackler Centre for Consciousness Science Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-08-21

First Open Access (FOA) Date

2019-08-12

First Compliant Deposit (FCD) Date

2018-08-17

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