Rethinking the reserve with a translational approach: novel ideas on the construct and the interventions

Serra, Laura, Gelfo, Francesca, Petrosini, Laura, Di Domenico, Carlotta, Bozzali, Marco and Caltagirone, Carlo (2018) Rethinking the reserve with a translational approach: novel ideas on the construct and the interventions. Journal of Alzheimer's disease, 65 (4). pp. 1065-1078. ISSN 1387-2877

[img] PDF - Accepted Version
Download (390kB)

Abstract

The concept of brain, cognitive, and neural reserves has been introduced to account for the apparent discrepancies between neurological damage and clinical manifestations. However, these ideas are yet theoretical suggestions that are not completely assimilated in the clinical routine. The mechanisms of the reserves have been extensively studied in neurodegenerative pathologies, in particular in Alzheimer's disease. Both human and animal studies addressed this topic by following two parallel pathways. The specific aim of the present review is to attempt to combine the suggestions derived from the two different research fields to deepen the knowledge about reserves. In fact, the achievement of a comprehensive theoretical framework on reserve mechanisms is an essential step to propose well-timed interventions tailored to the clinical characteristics of patients. The present review highlights the importance of addressing three main aspects: the definition of reserve proxy measures, the interaction between reserve level and therapeutic interventions, and the specific time-window of reserve efficacy.

Item Type: Article
Keywords: Alzheimer’s disease, animal studies, environmental enrichment, human studies, MRI, reserve mechanisms
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 01 Nov 2018 15:23
Last Modified: 01 Nov 2018 15:23
URI: http://srodev.sussex.ac.uk/id/eprint/79131

View download statistics for this item

📧 Request an update