Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS

Broad, Rebecca J, Gabel, Matt C, Dowell, Nicholas G, Schwartzman, David J, Seth, Anil K, Zhang, Hui, Alexander, Daniel C, Cercignani, Mara and Leigh, P Nigel (2018) Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050

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Abstract

Background Corticospinal tract (CST) degeneration and cortical atrophy are consistent features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation dispersion and density imaging (NODDI), a multicompartment model of diffusion MRI, would reveal microstructural changes associated with ALS within the CST and precentral gyrus (PCG) ‘in vivo’.

Methods 23 participants with sporadic ALS and 23 healthy controls underwent diffusion MRI. Neurite density index (NDI), orientation dispersion index (ODI) and free water fraction (isotropic compartment (ISO)) were derived. Whole brain voxel-wise analysis was performed to assess for group differences. Standard diffusion tensor imaging (DTI) parameters were computed for comparison. Subgroup analysis was performed to investigate for NODDI parameter differences relating to bulbar involvement. Correlation of NODDI parameters with clinical variables were also explored. The results were accepted as significant where p<0.05 after family-wise error correction at the cluster level, clusters formed with p<0.001.

Results In the ALS group NDI was reduced in the extensive regions of the CST, the corpus callosum and the right PCG. ODI was reduced in the right anterior internal capsule and the right PCG. Significant differences in NDI were detected between subgroups stratified according to the presence or absence of bulbar involvement. ODI and ISO correlated with disease duration.

Conclusions NODDI demonstrates that axonal loss within the CST is a core feature of degeneration in ALS. This is the main factor contributing to the altered diffusivity profile detected using DTI. NODDI also identified dendritic alterations within the PCG, suggesting microstructural cortical dendritic changes occur together with CST axonal damage.

Item Type: Article
Additional Information: Impact Factor: 7.144
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Neuroscience
School of Engineering and Informatics > Informatics
Research Centres and Groups: Centre for Computational Neuroscience and Robotics
Sackler Centre for Consciousness Science
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
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Depositing User: Patricia Butler
Date Deposited: 01 Nov 2018 12:04
Last Modified: 01 Nov 2018 12:04
URI: http://srodev.sussex.ac.uk/id/eprint/79137

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Project NameSussex Project NumberFunderFunder Ref
Neurite Orientation Dispersion and Density Imaging ('NODDI') - A New Approach to Understanding Cellular Pathology in MNDG1404MNDA-MOTOR NEURONE DISEASE ASSOCIATIONLeigh/Apr14/824-791