A central control circuit for encoding perceived food value

Crossley, Michael, Staras, Kevin and Kemenes, George (2018) A central control circuit for encoding perceived food value. Science Advances, 4 (11). pp. 1-11. ISSN 2375-2548

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Abstract

Hunger state can substantially alter the perceived value of a stimulus, even to the extent that the same sensory cue can trigger antagonistic behaviors. How the nervous system uses such graded perceptual shifts to select between opposed motor patterns remains enigmatic. Here we challenged food-deprived and satiated Lymnaea to choose between two mutually exclusive behaviors, ingestion or egestion, produced by the same feeding central pattern generator. Decoding the underlying neural circuit reveals that the activity of central dopaminergic interneurons defines hunger state and drives network reconfiguration, biasing satiated animals towards the rejection of stimuli deemed palatable by food-deprived ones. By blocking the action of these neurons, satiated animals can be reconfigured to exhibit a hungry animal phenotype. This centralized mechanism occurs in the complete absence of sensory retuning and generalizes across different sensory modalities, allowing food-deprived animals to increase their perception of food value in a stimulus-independent manner to maximize potential calorific intake.

Item Type: Article
Keywords: neuron, decision-making, feeding
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Subjects: Q Science > QP Physiology
Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system
Depositing User: Kevin Staras
Date Deposited: 12 Oct 2018 15:30
Last Modified: 18 Dec 2018 15:06
URI: http://srodev.sussex.ac.uk/id/eprint/79466

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Project NameSussex Project NumberFunderFunder Ref
Ultrastructure-function properties of recycling vesicle pools in native central synapsesG1150BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/K019015/1