Variability in the α and β anomer content of commercially available lactose

Jamal Altamimi, Mohamad, Wolff, Kim, Nokhodchi, Ali, Martin, Gary P and Royall, Paul G (2018) Variability in the α and β anomer content of commercially available lactose. International Journal of Pharmaceutics. ISSN 03785173 (Accepted)

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Abstract

Lactose, a disaccharide is a ubiquitous excipient in many pharmaceutical formulations which exists in two anomeric forms; either as - or -lactose. The anomers have different properties which can affect their application. Nevertheless, batches of lactose products are widely produced by many manufacturers, and is available in many grades. However, the anomeric content of these batches has not been accurately characterized and reported previously. Therefore, the aim of this study was to analyse a set of 19 commercially available samples of lactose using a novel H⁠1-NMR technique to establish a library showing the anomeric content of a large range of lactose products. The lactose samples were also analysed by DSC. The anomeric content of the -lactose monohydrate samples were found to vary by more than 10%, which might in_uence bioavailability from ^nal formulations. The data showed that there is a need to determine and monitor the anomeric content of lactose and this should be a priority to both manufacturers and formulators of medicines.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0189 Assay methods. Standardization. Analysis
R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0192 Pharmaceutical technology
Depositing User: Ali Nokhodchi
Date Deposited: 14 Nov 2018 15:12
Last Modified: 14 Nov 2018 15:12
URI: http://srodev.sussex.ac.uk/id/eprint/80230

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