EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation

Binabaj, Maryam Moradi, Asgharzadeh, Fereshteh, Avan, Amir, Rahmani, Farzad, Parizadeh, Mohammad Reza, Ferns, Gordon A, Ryzhikov, Mikhail, Khazaei, Majid and Hassanian, Seyed Mahdi (2018) EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation. Journal of Cellular Physiology. ISSN 0021-9541 (Accepted)

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EW-7197 is a TGF‐β type I receptor kinase inhibitor with potential anti-inflammatory and anti-fibrotic properties. Here, we investigate the potential therapeutic effects of EW-7197 in a murine model of ulcerative colitis. EW-7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW-7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW-7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing sub-mucosal edema and inflammatory cell infiltration, down-regulating pro-inflammatory and pro-fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW-7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis.
Keywords: EW-7197, TGF‐β signaling, Colitis, Inflammation, Fibrosis,

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 15 Nov 2018 16:41
Last Modified: 15 Nov 2018 16:41
URI: http://srodev.sussex.ac.uk/id/eprint/80234

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