Role of cytomegalovirus in driving cytotoxic CD28null T cells

Pera, Alejandra, Bano, Aalia and Kern, Florian (2018) Role of cytomegalovirus in driving cytotoxic CD28null T cells. In: Handbook of Immunosenescence. Springer, Cham, pp. 1-19. ISBN 9783319645971

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Abstract

Accumulation of CD28null T cells has been traditionally considered a sign of aging, as the percentage of these cells is increased in the elderly. However, the permanent loss of CD28 on T cells is caused by chronic antigenic stimulation. In that sense, CMV infection seems to be an important factor, particularly in the CD4 T-cell compartment, where significant expansions of these cells have been observed in CMV-seropositive individuals only and independently of age. In contrast to this, the CD28null CD8 T-cell subset is more heterogeneous, consisting of different type of cells with diverse origins, phenotype, and functions. Indeed, contrarily to their CD4 counterparts, CD28null CD8 T cells can be found expanded in the absence of CMV. CD28null CD4 T cells are cytotoxic and produce high amounts of pro-inflammatory cytokines. Expansions of these cells has been shown to be associated with many diseases and seems to have a relevant role in CVD (cardiovascular diseases). We, therefore, propose that CMV-related CVD risk may be mediated in part by CD28null CD4 T-cells, capable of damaging the vasculature.

Item Type: Book Section
Keywords: CD28null T cells CD57 CMV infection Age Cardiovascular disease
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine
R Medicine > R Medicine (General)
Depositing User: Sandy Gray
Date Deposited: 18 Dec 2018 13:30
Last Modified: 18 Dec 2018 13:30
URI: http://srodev.sussex.ac.uk/id/eprint/80874
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