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The clinical impact of exosomes in cardiovascular disorders: from basic science to clinical application

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journal contribution
posted on 2023-06-09, 16:17 authored by Farzaneh Ghafarian, Mehran Pashirzad, Majid Khazaei, Majid Rezayi, Seyed Mahdi Hassanian, Gordon FernsGordon Ferns, Amir Avan
Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of valid biomarker that accurately predict the risk of developing cardiovascular disease, and novel therapeutic approaches for its treatment. Exosomes are very small extracellular vesicles containing protein, lipid, transcription factors, mRNAs, non-coding RNA and nucleic acid contents, that are important players in intercellular communication, and that act via long-range signals or cell-to-cell contact. The discovery of exosomes provides potential strategies for the diagnosis and treatment of cardiovascular disease. In the current review, we have explored the potential impact of exosomes on cardiovascular physiology, and their therapeutic potential in cardiovascular disorders with a emphasize on the existing preclinical studies.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Cellular Physiology

ISSN

0021-9541

Publisher

Wiley

Issue

8

Volume

234

Page range

12226-12236

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-12-19

First Open Access (FOA) Date

2019-12-10

First Compliant Deposit (FCD) Date

2018-12-18

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