The clinical impact of exosomes in cardiovascular disorders: from basic science to clinical application

Ghafarian, Farzaneh, Pashirzad, Mehran, Khazaei, Majid, Rezayi, Majid, Hassanian, Seyed Mahdi, Ferns, Gordon A and Avan, Amir (2018) The clinical impact of exosomes in cardiovascular disorders: from basic science to clinical application. Journal of Cellular Physiology. ISSN 0021-9541

[img] PDF - Accepted Version
Restricted to SRO admin only until 10 December 2019.

Download (377kB)

Abstract

Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of valid biomarker that accurately predict the risk of developing cardiovascular disease, and novel therapeutic approaches for its treatment. Exosomes are very small extracellular vesicles containing protein, lipid, transcription factors, mRNAs, non-coding RNA and nucleic acid contents, that are important players in intercellular communication, and that act via long-range signals or cell-to-cell contact. The discovery of exosomes provides potential strategies for the diagnosis and treatment of cardiovascular disease. In the current review, we have explored the potential impact of exosomes on cardiovascular physiology, and their therapeutic potential in cardiovascular disorders with a emphasize on the existing preclinical studies.

Item Type: Article
Keywords: exosomes, Cardiovascular diseases, nucleic acid contents, biomarker
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 19 Dec 2018 10:42
Last Modified: 19 Dec 2018 10:43
URI: http://srodev.sussex.ac.uk/id/eprint/80892

View download statistics for this item

📧 Request an update