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A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls
journal contribution
posted on 2023-06-09, 16:27 authored by Sayyed Saeid Khayyatzadeh, Mehrane Mehramiz, Habibollah Esmaeily, Seyed Jamal Mirmousavi, Leila Khajavi, Fatemeh Nejati Salehkhani, Parichehr Hanachi, Hamidreza Bahrami-Taghanaki, Saeed Eslami, Hasan Vatanparast, Gordon FernsGordon Ferns, Amir Avan, Majid Ghayour-MobarhanAim The determinants of serum vitamin D seems to be the environmental factors (dietary and supplementary intake and exposure to ultraviolet light) and genetic factors. We aimed to study the relationship between a vitamin D-associated genetic polymorphism and serum 25(OH)D concentrations in healthy adolescent girls in Iran, and its effects on a high-dose supplement of vitamin D. Material and method A total of 616 healthy adolescent girls with mean age 15 received 50,000 IU of vitamin D3 weekly over 9 weeks. Serum vitamin D levels and other metabolic factors were measured at baseline and after the intervention. The genotyping of the CYP2R1 variant (rs10741657) was performed by TaqMan genotyping assays. Results Regardless of the genetic background, at baseline, 87% of adolescent girls were vitamin D deficient (serum 25(OH)D level?
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Cellular PhysiologyISSN
0021-9541Publisher
WileyExternal DOI
Issue
8Volume
234Page range
13977-13983Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-01-09First Open Access (FOA) Date
2020-01-09First Compliant Deposit (FCD) Date
2019-01-08Usage metrics
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