Emerging magnetic resonance imaging techniques and analysis methods in amyotrophic lateral sclerosis

Barritt, Andrew W, Gabel, Matt C, Cercignani, Mara and Leigh, P Nigel (2018) Emerging magnetic resonance imaging techniques and analysis methods in amyotrophic lateral sclerosis. Frontiers in Neurology, 9. 1065 1-8. ISSN 1664-2295

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Abstract

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral sclerosis in order to more eloquently stratify the highly heterogeneous phenotype and facilitate the discovery of effective disease modifying treatments for patients. Magnetic resonance imaging (MRI) is a promising, non-invasive biomarker candidate whose acquisition techniques and analysis methods are undergoing constant evolution in the pursuit of parameters which more closely represent biologically-applicable tissue changes. Neurite Orientation Dispersion and Density Imaging (NODDI; a form of diffusion imaging), and quantitative Magnetization Transfer Imaging (qMTi) are two such emerging modalities which have each broadened the understanding of other neurological disorders and have the potential to provide new insights into structural alterations initiated by the disease process in ALS. Furthermore, novel neuroimaging data analysis approaches such as Event-Based Modeling (EBM) may be able to circumvent the requirement for longitudinal scanning as a means to comprehend the dynamic stages of neurodegeneration . Combining these and other innovative imaging protocols with more sophisticated techniques to analyse ever-increasing datasets holds the exciting prospect of transforming understanding of the biological processes and temporal evolution of the ALS syndrome, and can only benefit from multicentre collaboration across the entire ALS research community.

Item Type: Article
Keywords: magnetic resonance imaging; event-based model; motor neuron disease; neurite orientation dispersion and density imaging (NODDI); quantitative magnetization transfer imaging
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
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Depositing User: Patricia Butler
Date Deposited: 25 Jan 2019 12:52
Last Modified: 25 Jan 2019 14:45
URI: http://srodev.sussex.ac.uk/id/eprint/81458

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