Glucose-6-phosphate dehydrogenase status and risk of hemolysis in plasmodium falciparum-infected African children receiving single-dose primaquine

Eziefula, Alice C, Pett, Helmi, Grignard, Lynn, Opus, Salome, Kiggundu, Moses, Kamya, Moses R, Yeung, Shunmay, Staedke, Sarah G, Bousema, Teun and Drakeley, Chris (2014) Glucose-6-phosphate dehydrogenase status and risk of hemolysis in plasmodium falciparum-infected African children receiving single-dose primaquine. Antimicrobial Agents and Chemotherapy, 58 (8). pp. 4971-4973. ISSN 0066-4804

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Abstract

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine
Depositing User: Deborah Miller
Date Deposited: 28 Feb 2019 17:11
Last Modified: 28 Feb 2019 17:11
URI: http://srodev.sussex.ac.uk/id/eprint/82271

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