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White_assessment of therapeutic responses to gametocytocidal drugs in PF_MJ 2014.pdf (2.24 MB)

Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

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posted on 2023-06-09, 17:06 authored by Nicholas J White, Elizabeth A Ashley, Judith Recht, Michael J Delves, Andrea Ruecker, Frank M Smithuis, Chi EziefulaChi Eziefula, Teun Bousema, Chris Drakeley, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Jetsumon Prachumsri, Cindy Chu, Chiara Andolina, Germana Bancone, Tran T Hien, Mayfong Mayxay, Walter RJ Taylor, Lorenz von Seidlein, Ric N Price, Karen I Barnes, Abdoulaye Djimdé, Feiko ter Kuile, Roly Gosling, Ingrid Chen, Mehul J Dhorda, Kasia Stepniewska, Philippe Guérin, Charles J Woodrow, Arjen M Dondorp, Nicholas PJ Day, Francois H Nosten
Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

History

Publication status

  • Published

File Version

  • Published version

Journal

Malaria Journal

ISSN

1475-2875

Publisher

BMC

Issue

483

Volume

13

Page range

1-13

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-03-04

First Open Access (FOA) Date

2019-03-04

First Compliant Deposit (FCD) Date

2019-03-01

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