Al-hilaly-2019-1.pdf (3.73 MB)
The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?
journal contribution
posted on 2023-06-09, 17:09 authored by Yann Fichou, Youssra Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise SerpellLouise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle LandrieuInsights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer’s and Pick’s disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics.
History
Publication status
- Published
File Version
- Published version
Journal
Acta Neuropathologica CommunicationsISSN
2051-5960Publisher
BMCExternal DOI
Issue
31Volume
7Page range
1-17Pages
31.0Department affiliated with
- Biochemistry Publications
Notes
Unmapped bibliographic data: JO - Acta Neuropathologica Communications [Field not mapped to EPrints]Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-03-07First Open Access (FOA) Date
2019-03-07First Compliant Deposit (FCD) Date
2019-03-05Usage metrics
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