Baraniak, Ilona, Kern, Florian, Holenya, Pavlo, Griffiths, Paul and Reeves, Matthew (2019) Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive recipients. The Journal of Infectious Diseases. ISSN 0022-1899

PDF (This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Infectious Diseases following peer review. The version of record is available online at: http://dx.doi.org/10.1093/infdis/jiz089) - Accepted Version Restricted to SRO admin only until 27 February 2020. Download (794kB)

Abstract

A cytomegalovirus (CMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in CMV infected individuals (CMV+). Using sera from CMV+ gB/MF59 vaccine recipients prior to transplant we investigated the composition of the immune response. Vaccination boosted pre-existing humoral responses in our CMV+ cohort but did not promote de-novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination (‘original antigenic sin’). Thus vaccination of CMV+ may require strategies of epitope presentation distinct from those intended to prevent primary infection.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Brighton and Sussex Medical School Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User:	Sandy Gray
Date Deposited:	07 Mar 2019 11:25
Last Modified:	21 Mar 2019 16:28
URI:	http://srodev.sussex.ac.uk/id/eprint/82365

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