Predictive mathematical models for the spread and treatment of hyperoxia-induced photoreceptor degeneration in retinitis pigmentosa

Roberts, Paul A, Gaffney, Eamonn A, Whiteley, Jonathan P, Luthert, Philip J, Foss, Alexander J E and Byrne, Helen M (2018) Predictive mathematical models for the spread and treatment of hyperoxia-induced photoreceptor degeneration in retinitis pigmentosa. Investigative Ophthalmology & Visual Science, 59 (3). pp. 1238-1249. ISSN 1552-5783

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)
[img] PDF - Accepted Version
Restricted to SRO admin only

Download (5MB)


Purpose: To determine whether the oxygen toxicity hypothesis can explain the distinctive spatio-temporal patterns of retinal degeneration associated with human retinitis pigmentosa (RP) and to predict the effects of antioxidant and trophic factor treatments under this hypothesis.

Methods: Three mathematical models were derived to describe the evolution of the retinal oxygen concentration and photoreceptor density over time. The first model considers only hyperoxia-induced degeneration, while the second and third models include mutation-induced rod and cone loss respectively. The models were formulated as systems of partial differential equations, defined on a two-dimensional domain spanning the region between the foveal center and the ora serrata, and were solved numerically using the finite element method.

Results: The mathematical models recapitulate patterns of retinal degeneration which involve preferential loss of photoreceptors in the parafoveal/perifoveal and far-peripheral retina, while those which involve a preferential loss of midperipheral photoreceptors cannot be reproduced. Treatment with antioxidants or trophic factors is predicted to delay, halt, or partially reverse retinal degeneration, depending upon the strength and timing of treatment and disease severity.

Conclusions: The model simulations indicate that while the oxygen toxicity hypothesis is sufficient to explain some of the patterns of retinal degeneration observed in human RP, additional mechanisms are necessary to explain the full range of behaviors. The models further suggest that antioxidant and trophic factor treatments have the potential to reduce hyperoxia-induced disease severity and that, where possible, these treatments should be targeted at retinal regions with low photoreceptor density to maximize their efficacy.

Item Type: Article
Keywords: retinitis pigmentosa, mathematical model, finite element method, photoreceptors, oxygen toxicity
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Subjects: Q Science > QA Mathematics
R Medicine > RE Ophthalmology
Depositing User: Paul Roberts
Date Deposited: 12 Mar 2019 13:25
Last Modified: 12 Mar 2019 13:26

View download statistics for this item

📧 Request an update